I suppose you could, but being that it’s Debian based I’d say just use Debian.

Any particular reason?

Why? It’s a desktop distro based on Debian. Just use Debian.

Used it in the past, and it’sa pretty alright desktop OS. It would work as a server OS, but that’s not really its main focus.

It’s debian based, so might as well go for actual debian.

Proxmox

I’d have to disagree; Proxmox is definitely the sweet spot for a self-hosting setup.