Does LMDE do wayland? If not, I wouldn’t bother.
Bazzite or some other Fedora variant. Nobara has some tweaks for nVidia, full codec support, and specifically supports programs like daVinci Resolve, KDenlive and OBS Studio in the Welcome screen. Not an immutable distro like Bazzite though, which depending on how you like to install stuff, might not be a bad thing.
Don’t expose things to the internet with port forwards. Anything you want to do like that can be done with a reverse proxy or preferably a VPN.
That is all.